腹腔化疗和静脉化疗对免疫的影响

Effect of early postoperative intraperitoneal chemotherapy versus that of intravenous chemotherapy on the immunity of patients with gastrointestinal carcinoma

目的 比较术后腹腔化疗和静脉化疗对胃肠道癌患者免疫的影响。方法 将 36例胃肠道癌患者分两组 ,每组 18例 ,一组接受腹腔化疗 ,另一组接受静脉化疗 ,检测血清中T细胞亚群和sIL 2R水平。结果 血清CD3、CD4和sIL 2R水平化疗后较化疗前明显下降 (P <0 .0 1)。CD3、CD4、CD8在两治疗组之间相似 (P >0 .1) ,但sIL -2R水平腹腔化疗较静脉化疗低 ( 0 .0 5<P <0 .1)。结论 腹腔化疗比静脉化疗对机体免疫的影响小 ,提倡多疗程的腹腔化疗。

Objective TO compare the effect of early postoperative intraperitoneal chemotherapy (EPIC) with that of intravenous chemotherapy (IVC)on the immunity of patients with gastrointestinal carcinoma (GC).Methods 36 patients were divided into two groups each with 18 cases, one group received EPIC and the other IVC, then determined the serum T-lymphocyte subsets (T LS) and sIL-2R before and after the chemotherapy.Results Serum CD3, CD4 and sIL 2R in GC patients after the chemotherapy decreased more significantly than those of before the chemotherapy (P<0.01), serum CD3,CD4,CD8 levels were similar between two groups (P>0.1),but mean sIL 2R level in EPIC group was lower than that in IVC (0.05<P<0.1).Conclusion EPIC affects the immunity more moderate than IVC and should be recommended as possible.