摘要
采用气传真菌孢子混合悬液气管染毒大鼠 ,并以逆转录聚合酶链式反应的方法观察了大鼠外周血单个核细胞 (PBMCs)白细胞介素 4(IL 4)细胞因子mRNA表达情况。结果表明 ,气传真菌孢子气管染毒大鼠可使其外周血单个核细胞高表达IL 4mRNA。实验结果提示IL 4在真菌所致过敏反应中有重要作用。
The effect of indoor airborne fungi on interleukin 4 (IL 4) mRNA expression in the peripheral blood mononuclear cells (PBMCs) of rats was studied by inoculating via trachea with fungi suspension. A simplified competitive RT PCR method was used to measure the IL 4 mRNA expression in plasma. The results showed that interleukin 4 expression was much higher in the affected groups than that in the control one. It suggested that IL 4 might play an important role in the sensitization progress of fungi.
出处
《卫生研究》
CAS
CSCD
北大核心
2001年第5期269-270,共2页
Journal of Hygiene Research
基金
卫生部科技基金资助项目 (No.98 1 1 67)
