稀土元素铈对细胞内活性氧的影响

Effect of Ce^(3+) on reactive oxygen species in cells

运用显微荧光术研究了Ce3+ 对肝细胞和V79细胞中活性氧 (ROS)的影响。结果表明 ,低浓度的Ce3 + 能显著降低细胞内ROS浓度 ,而高浓度的Ce3+ 能显著提高细胞内ROS的浓度。结果提示 ,低浓度的Ce3 + 可能减少脂质过氧化损伤或DNA氧化损伤 ,高浓度的Ce3 + 可能增加脂质过氧化损伤或DNA氧化损伤。

The effect of Ce 3+ on the content of (reactive oxygen species ROS) in hepatocytes and V79 cells was studied with microfluorometry. The results showed that Ce 3+ could enhance the concentration of ROS in hepatocytes in high dose and reduce the concentration of ROS in low dose. These results suggested that Ce 3+ might decrease the damage of lipid peroxidation and DNA in low dose and might increase the damage of lipid peroxidaion and DNA in high dose.