血浆同型半胱氨酸与原发性高血压及缺血性脑卒中的关系

Plasma Levels of Homocysteine in Hypertensive Patients with or Without Stroke

目的 :探讨血浆同型半胱氨酸 (Hcy)与原发性高血压及相关缺血性脑卒中的关系。 方法 :高效液相色谱法对 2 36例门诊和住院的原发性高血压及健康查体者进行血浆Hcy测定。根据病史及体格检查将受检者分为对照组 (健康查体者 40例 )、单纯血压增高组 ( 112例 )及原发性高血压并缺血性脑卒中组 ( 84例 )。 结果 :血浆Hcy水平 :单纯血压增高组 ( 13 5± 8 1μmol/L)、原发性高血压合并脑卒中组 ( 16 6± 10 3μmol/L)均高于对照组 ( 8 2± 2 5 μmol/L) ,有非常显著性差异 (P <0 0 0 1)。原发性高血压并脑卒中组与单纯血压增高组相比 ,亦有明显差异 ,P <0 0 5。 结论 :原发性高血压患者血浆Hcy升高。当合并缺血性脑卒中时 ,血浆Hcy水平则更高。

Objective:We examined the relationship between homocysteine and hypertension with or without stroke. Methods:The plasma levels of homocysteine in 236 subjects were measured by high-performance liquid chromatography.Subjects(n=40)without hypertension history were served as controls.Others were divided into hypertension group(n=112)and hypertension cerebral event group(stroke group n=84). Results:Mean plasma level of homocysteine were higher in hypertensive patients than in controls(13.5±8.1*!μmol/L versus 8.2±2.5*!μmol/L,p<0.001)and even higher in the stroke group(16±6.2*!μmol/L,p<0.001). Conclusion:Homocysteine level is higher in hypertensive patients,and still higher in those with hypertensive cerebral events.