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房水PAI-1与后房型人工晶体前纤维蛋白膜的关系

Study of the Relation Between Aqueous PAI-1 and the Formation of Anterior Fibrinous Membrane of PcIOL
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摘要 目的探讨房水微环境纤溶系统对后房型人工晶体IOL(posteriorchamberIOL ,PcIOL)前纤维蛋白膜形成的影响。 方法测定 31例白内障患者术前房水中纤溶酶原激活物抑制剂 (plasminogenactivatorinhibitor- 1,PAI- 1)含量 ,观察术眼术后PcIOL前纤维蛋白膜形成情况 ,根据术前患眼的病史 ,分为葡萄膜炎组、青光眼组及对照组并进行统计学分析。 结果术前有葡萄膜炎和青光眼病史的患眼术后PcIOL前纤维蛋白膜的发生率和术前房水中PAI - 1含量均显著高于对照眼。白内障术后PcIOL前有纤维蛋白膜形成眼的术前房水中PAI - 1含量 (5 .0 1± 2 .96ng/ml)显著高于术后无纤维蛋白膜眼 (1.2 3± 1.42ng/ml) (P <0 .0 5 )。青光眼组PcIOL前纤维蛋白膜形成眼术前房水PAI- 1含量 (5 .95± 2 .42ng/ml)显著高于无纤维蛋白膜眼 (1.6 4± 0 .91ng/ml) (P <0 .0 5 )。 Objective To investigate the effect of aqueous plasminogen activator inhibitor-1 (PAI-1) on the formation of the anterior fibrinous membrane of PcIOL. Methods The components of aqueous PAI-1 were determined in 31 cataract eyes preoperatively. According to the preoperative history of eye disorders, the eyes were divided into three groups: uveitis, glaucoma and control. Statistical analysis was performed to determine the possible effects of preoperative history and aqueous PAI-1 on the formation of the anterior fibrinous membrane of PcIOL. Results More anterior fibrinous membranes and high components of aqueous PAI-1 were seen in the uveitis and glaucoma eyes than the controls. The mean component of aqueous PAI-1 in the eyes with the anterior fibrinous membrane (5.01± 2.96ng/ml) was significantly higher than those without the membrane (1.23±1.42ng/ml) (P<0.05). In glaucoma eyes, the mean component of aqueous PAI-1 in the eyes with the anterior fibrinous membrane postoperatively (5.95±2.42ng/ml) was significantly higher than those without the membrane (1.64±0.91ng/ml) (P<0.05). Conclusion Destruction of the aqueous fibrolytic system may promote the formation of the anterior fibrinous membrane of PcIOL.
作者 孙悦 王玲
出处 《上海第二医科大学学报》 CSCD 2001年第5期408-410,共3页 Acta Universitatis Medicinalis Secondae Shanghai
关键词 后房型人工晶体 前纤维蛋白膜 房水 纤溶酶原激活物抑制剂 PcIOL anterior fibrinous membrane aqueous humor PAI-1
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