大黄水提物的促智作用研究

Effect of Rheum palmatum Decoction on Increasing Intelligence

目的:观察大黄水提物对小鼠促智作用的影响。方法:跳台法。结果:大黄水提物能增强自然衰老小鼠的学习和记忆能力,并对由东莨菪碱、亚硝酸钠和40％乙醇分别引起的小鼠记忆获得、巩固及再现障碍病理模型有较明显的改善作用。结论:大黄水提物中含有促智作用的药效物质,它可能是临床常用以大黄为主药的汤剂治疗中风失语、老年记忆障碍、脑外伤后遗症等疾病并获良效的物质基础。

Objective: To observe the nootropic effect of Rheum pahnatum decoction in mice. Method: Step - down test. Results; Rheum palmatum decoction could increase learning and memory ability of old mice and also improve the impainnents of memory acquisition, memory consolidation and memory retrieval induced by scopalamine, NaNO2 and 40% EtOH respectively in mice. Conclusion: Rheum palmatum decoction contains the substances of increasing intelligence which may be substantial basis of the decoctions mainly containing Rheum palmatum threraping aphasia from apoplexy, senile dysmnesia, sequel from brain trauma, etc.