红花黄色素在急性血瘀大鼠体内的药代动力学研究

Pharmacokinetical Study of Safflor Yellow on Rat Acute Model of Blood Stasis Syndrome

目的:考察红花黄色素(safflor yellow,SY)在急性血瘀大鼠体内的药代动力学特征。方法:通过皮下注射肾上腺素(0.07ml/kg)和冰水刺激造成大鼠急性血瘀模型后,将正常组和模型组分别尾静脉注射红花黄色素注射液(37.08mg/kg),并测定大鼠在5、10、30、60、120、180、300和480min血清样品中药物浓度。结果:血瘀大鼠的血药浓度-时间曲线符合二室开放模型,曲线下的面积(AUC)为49633μg·min/ml,分布半衰期(t_((1/2)α))为1.43min,消除半衰期(t_((1/2)β))为95.65min;而正常大鼠为一室模型,曲线下的面积(AUC)为42267μg·min/ml,半衰期(t_(1/2))为66.27min。结论:红花黄色素在急性血瘀大鼠体内代谢明显慢于正常大鼠体内的代谢。

Objective: To study the pharmacokinetical character of safflor yellow in rat acute model of blood stasis syndrome. Methods: The rat acute model of blood stasis syndrome was made by ip adrenalin (0.07 ml/kg) and the stimulation of ice-water. At the time of 5,10, 30,60,120,180,320,480 min, the concentration of safflor yellow in the serum after iv safflor yellow (37.08 ml/kg) was determined. Results: The concentration-time date of safflor yellow in rat acute model of blood stasis syndrome was shown to fit a double -compartment open model, t1/2α= 1.43min,t1/2β= 95.65min, AUC = 49632.90μg·min/ml;while the concentration-time data of safflor yellow in normal rat was shown to fit a single-compartment open model, t1/2α= 66.27 min, AUC = 42267 μg·min/ml. Conclusion: The metabolism of safflor yellow was evidenly later in rat acute model of blood stasis syndrome than in normal rat.