erbB2/HER2在肺癌组织中的表达及意义

Study on erbB2/HER2 Expression in Lung Cancer

目的:研究erbB2基因在肺癌的表达。方法:应用免疫组织化学的方法检测20例正常肺组织和60例肺癌HER2第二人体表皮生长因子受体,humanepidermalgrowthfactorreceptor2HER2蛋白的表达。结果:HER2在正常肺组织无过度表达,肺癌中存在HER2的过度表达,过度表达率为667%,肺癌HER2的过度表达更多见于中晚期的肺癌,且与患者术后3年生存率呈负相关。结论:HER2在正常肺组织无过度表达,在肺癌中存在过度表达,提示erbB2基因编码的HER2蛋白在细胞的正常生长及肺癌的发展中均起一定的作用,有可能成为观察肺癌预后的一个指标。

Object ive：To investigate the erbB２expression in lung cancer．Methods：Twenty samples of paraf－fin－embedded normal lung tissues an d ６０samples of paraffin－embed ded lu ng cancer from the patients with lung cancer were examined for erbB２expr ession by immunohistochemistry．Results：HER２was underexpressed in normal lu ng tissues and overex－pressed in lung cancer．The HER２overexpression in lung can cer was associated with clinical stage and was reversely correlat－ed with posto perative survival．Conclusion：The underexpression of HER２in norma l lung tissu es and the overexpressio n in lung cancer suggest that HER２tends t o be associa ted with the normal cell g rowth and the development of lung can cer and might b e a mark for the prognosis of lu ng cancer．