不同制备工艺的瓜蒌薤白提取物药效学比较

Comparison on Pharmacodynamics Effects between Different Extracts of Fructus Trichosanthis and Bulbus Allii Macrostemi

目的 :对不同工艺制备的瓜蒌薤白提取物 (分别简称为水提物WE及醇提物EE)进行药效学比较研究。方法 :采用小鼠常压耐心肌缺氧模型 ,豚鼠离体心脏冠脉流量及体外抗血小板聚集等药效学试验。结果 :EE可明显延长小鼠在常压缺氧情况下的存活时间 ,而相同剂量的WE则无效 ;相同剂量的EE及WE对离体豚鼠心脏均具有明显的扩冠作用 ,并均可抑制由ADP诱导的血小板聚集。结论 :相同剂量的EE的药理作用略优于WE。

Objective: To compare pharmacodynamics properties between the extracts of Fructus Trichosanthis and Bulbus allii(water extraction, WE; ethanol extraction, EE). Methods: To establish model of normobaric hypoxia in mice with isoprenaline; determinated the coronary blood flow of isolated guinea pig heart and rabbits platelet aggregation induced by ADP in vitro. Results: EE was more effective than WE on the prolongation of survival time of mice; EE and WE significantly increased coronary blood flow and inhibited platelet aggregation at the same dose. Conclusion: At the same dose, the effect of EE is superior to WE.