细梗紫菊中的化学成分

Chemical constituents of Notoseris gracilipes

目的 对细梗紫菊 N otoseris gracilipes全草的化学成分进行分离纯化、结构鉴定和抗菌活性测试。方法 以甲醇室温提取 ,采用各种色谱技术进行分离纯化 ,根据 NMR等波谱数据鉴定结构 ,按常规方法进行抗菌活性的定性测定。结果 从细梗紫菊全草的甲醇提取物中分离鉴定出 12个化合物 ,其中 8个为倍半萜内酯 :jacquilenin( ) ,scorzoside( ) ,ixerisoside D( ) ,austricin( ) ,notoserolide A( ) ,crepidiaside A( ) ,crepidiaside B( )和 lactuside B( )。另外 4个化合物分别鉴定为 6 ,7-二羟基香豆素 ( ) ,野莴苣苷 ( ) ,木犀草素 - 7-葡萄糖苷( )和胡萝卜苷 ( ) ,倍半萜内酯的抗菌实验表明化合物 和 对蜡状芽孢杆菌 (Bacillu cereus AS.1.16 88)的生长有抑制作用。结论 这些化合物均为首次从该植物中分离得到目的 对细梗紫菊 N otoseris gracilipes全草的化学成分进行分离纯化、结构鉴定和抗菌活性测试。方法 以甲醇室温提取 ,采用各种色谱技术进行分离纯化 ,根据 NMR等波谱数据鉴定结构 ,按常规方法进行抗菌活性的定性测定。结果 从细梗紫菊全草的甲醇提取物中分离鉴定出 12个化合物 ,其中 8个为倍半萜内酯 :jacquilenin( ) ,scorzoside( ) ,ixerisoside D( ) ,austricin( ) ,notoserolide A(

Object To investigate the chemical constituents from the whole plant of Notoseris gracilipes Shih Methods Compounds were isolated by various column chromatography and identified by spectral analysis Results Eight sesquiterpene lactones and four other compounds were isolated and identified as jacquilenin (Ⅰ), scorzoside (Ⅱ), ixerisoside D (Ⅲ), austricin (Ⅳ), notoserolide A (Ⅴ), crepidiaside A (Ⅵ), crepidiaside B (Ⅶ), and lactuside B (Ⅷ) The other four were 6, 7 dihydroxycoumarin (Ⅸ), cichoriin (Ⅹ), luteolin 7 glucoside (Ⅺ), and daucosterol ( ⅩⅡ ) Among them, compounds Ⅰ and Ⅱ showed antibacterial activity against Bacillu cereus AS 1 1688 Conclusion All compounds were isolated from this plant for the first time