摘要
目的 对山茱萸提取液抗心律失常有效部位进行研究。方法 山茱萸提取液对氯仿诱发小鼠室颤模型的作用 ,对豚鼠离体乳头肌电生理效应。结果 山茱萸提取液抗心律失常作用可能与延长心肌动作电位、增大静息电位绝对值和降低窦房结自律性有关。其抗心律失常的有效部位为总有机酸和一种未知的微量成分。总苷类不具有抗心律失常活性。结论 药效学及心肌电生理实验结果表明 。
Object To study the effective portion in Cornus officinalis Sieb. et Zucc. extract (COE) for the treatment of arrhythmia. Methods Effect of COE on chloroform induced ventricular fibrillation in mice and electrophysiology of isolated guinea pig papillary muscle were studied. Results Antiarrhythmic effect of COE may be related to its prolongation of action potential duration, increase of the absolute value of resting potential and a decrease of autonomy of sinus node. The effective portion in COE may be its total organic acid and a certain yet unknown trace substance, whereas its total glycosides were devoid of such activities. Conclusion Pharmacodynamic and myocardial electrophysiologic studies showed that the total organic acid and a certain unknown trace substance possessed the obvious antiarrhythmic activity.
出处
《中草药》
CAS
CSCD
北大核心
2001年第11期1004-1007,共4页
Chinese Traditional and Herbal Drugs
基金
河北省科学技术与发展规划 ( No.992 76 42 1D)资助项目
关键词
山茱萸提取液
抗心律失常
电生理
动作电位
乳头肌
中医药治疗
动物模型
extract of Cornus officinalis Sieb. et Zucc.
antiarrhythmia
electrophysiology
action potential
papillary muscle