PIE方案治疗复发性卵巢上皮癌疗效分析

Analysis for PIE chemotherapy to recurrent ovarian epithelial carcinoma

目的:探讨复发性卵巢上皮癌 PIE方案二线化疗的疗效、可行性及影响因素。方法:回顾性分析 12例复发及进展性卵巢上皮性恶性肿瘤用顺铂 +异环磷酰胺 +足叶乙甙方案化疗的效果。结果:二线化疗有效率 75 %(9/ 12 ) ;二线化疗后平均生存期 13.7个月 ,其中远期复发 (复发时间 >1年 )者平均生存期 17.1个月 ,近期复发 (复发时间 <1年 )者平均生存期 5 .3个月 ;复发无腹水者平均生存期 18.4个月 ,伴腹水者平均生存期 8.6个月。 结论 :顺铂、异环磷酰胺加足叶乙甙联合化疗治疗复发性上皮性卵巢癌有一定疗效 ;对初治有效或局限性复发者效果较明显 。

Objective: To study the effect, feasibility and influence factors of PIE chemotherapy as a second line regime of chemotherapy for recurrent ovarian epithelial carcinoma(OEC). Methods: Twelve patients with recurrent or progressive OEC were treated with cisplatin, ifosfamide and etoposide and analyzed retrospectively. Results: Response rate of PIE regime was 75%. Mean survival was 13.7 months (range 4～29) after second line therapy. Mean survival in those cases of recurrence beyond one year and recurrence in less than one year were 17.1 months and 5.3 months respectively (P<0.05). And mean survival in patients of recurrence without ascites and with ascites were 18.4 months and 8.6 months respectively (P<0.05). Conclusion: PIE chemotherapy is a practical and effective second line therapy regime for patients with recurrent or progressive OEC. Moreover, those patients who responsed to first treatment and whose recurrence without ascites had better response.