良性前列腺增生症临床症状参数与组织学成分间的相关关系

The relationship between clinical symptomatic parameters and prostatic histologic compositions in patients with benign prostatic hyperplasia

目的 探讨良性前列腺增生 (BPH)临床症状参数与组织学成分间的相关关系。 方法 对 86例BPH患者的年龄、前列腺体积、国际前列腺症状评分 (IPSS)和最大尿流率 (Qmax)进行回顾性分析 ,应用HE染色结合计算机图像分析对前列腺组织构成成分进行形态学定量分析 ,并与临床参数间进行相关分析。 结果 BPH患者年龄与前列腺体积和IPSS呈密切正相关 ,与Qmax和组织学成分间无显著相关。前列腺体积与IPSS和Qmax间也无相关 ,但与间质面积和腺腔面积之间密切相关。间质面积和间质 /上皮比例分别与IPSS和Qmax之间密切相关。前列腺体积 >30ml者间质面积显著低于前列腺体积≤ 30ml者 ,但腺腔面积前者显著高于后者。 结论 BPH患者的临床症床参数及组织构成成分之间存在相关性 。

Objective To investigate the relationship between age,prostatic volume,International Prostate Symptom Score (IPSS),maximal flow rate (Qmax) and prostatic histologic compositions in patients with benign prostatic hyperplasia (BPH). Methods 86 cases of BPH were retrospectively analysed on age,prostatic volume,IPSS and Qmax.The area densities of stroma,epithelium and glandular lumen of BPH tissues were determined by computer-assisted quantitative morphometry analysis system. Results Age correlated with prostatic volume ( r =0.354, P <0.001) and IPSS ( r =0.283, P <0.01),whereas it weakly correlated with Qmax ( r =-0.192, P =0.06) and insignificantly correlated with prostatic histologic compositions ( P >0.05).There was a weak correlation bewteen prostate volume and IPSS ( r = 0.17 , P >0.05),and Qmax ( r =-0.206, P >0.05),however,there was a close correlation with area densities of stroma ( r =-0.33, P <0.01) and glandular lumen ( r =0.24, P <0.05).Of five indexes of prostatic histologic compositions,only area density of stroma and the ratio of stroma to epithelium were significantly related to IPSS and Qmax.There was a statistically significant difference in area densities of stroma and glandular lumen when comparing prostate volume less than 30ml versus greater than 30ml,including stroma 70.3% versus 55.7%( P <0.01) and glandular lumen 21.2% versus 26.7%( P <0.05). Conclusions There are close and significant correlationship among clinical symptom parameters and histologic compositions in patients with BPH.It may be helpful in selecting effective drugs for BPH.