C反应蛋白与冠心病的相关性研究

Study of correlation between C-reactive protein and coronary heart disease

目的 :探讨 C反应蛋白 (CRP)与冠心病发生、发展的关系及其对预后的预测价值。方法 :采用免疫透射比浊法测定 136例入选对象 CRP的含量。其中冠心病 10 6例 ,包括稳定型心绞痛 (SAP)组 38例。不稳定型心绞痛(USAP)组 39例、急性心肌梗死 (AMI)组 2 9例 ;正常对照组 30例。结果 :(1)冠心病患者中 CRP异常升高率为 6 7.9% ;(2 ) SAP组 CRP有所升高 ,但无统计学意义 ;USAP和 AMI组较正常对照组 CRP明显升高 (P均 <0 .0 1) ;(3) AMI的 CRP水平较 USAP组更高 (P<0 .0 5 )。结论 :CRP升高是冠心病发生、发展的危险因素之一 ,它与冠心病严重程度呈正相关 。

Objective:Toe explore the correlation between C\|reactive protein(CRP) and coronary heart disease(CHD) and its prognostic value.Methods:The plasma CRP levels of 136 patients were determined by immune transmission turbidity method.In which 38 cases were stable angina pectoris(SAP),39 cases were unstable angina pectoris(USAP),29 cases were myocardial infarction(AMI),30 cases were normal controls.Results:(1)CRP positive rate was 67 9% in CHD patients;(2)CRP positive level increased in SAP group,but not significant difference when compared with control group;(3) The CRP positive levels of SAP and AMI group significantly increased( P <0 01) when compared with control group,but its level of AMI group more increased( P <0 05).Conclusion:The CRP positive level increase is a risk factor of CHD.Its level is positive correlation with severity extent of CHD,and it is a valuable index on predicting prognosis.