端粒酶及其抑制剂的研究进展

Progress in Telomerase and the Inhibitors

细胞分裂中染色体因其末端的DNA不能完全复制而短缩,使细胞逐渐失去增殖能力,导致细胞衰老、死亡。端粒酶的活化可延长染色体的末端DNA,维护基因组的稳定。端粒酶活性的异常表达,又会使细胞永生化或转化成癌细胞。因此,端粒酶在控制细胞寿命方面有重要作用,端粒酶活性抑制剂有望成为治疗肿瘤的新药物。

In cells division chromosome length is shorten for the ending DNA couldn′t be replicated completely, and the loss of telomere DNA will lead to senescence and death. Activation of telomerase can elongate telomere length and maintain gene stability. Up\|regulation of telomerase is considered to be responsible for immortalization and carcinogenesis. It plays an important role in cell\|span and cell division. The telomerase inhibitors will become efficient drugs in tumor therapy.