摘要
目的 :比较非洛地平、硝苯地平缓释片的降压疗效。方法 :原发性轻、中度高血压病人 12 4例 ,分为非洛地平组 6 6例 ,应用非洛地平 (5mg、qd、po) ,硝苯地平缓释片组 5 8例 ,应用硝苯地平缓释片 (30mg ,qd ,po) ,均连续应用 8周。结果 :2药降压有效率分别为 79% ,80 % ,2药比较差异不显著。其中原发性轻度高血压患者 2药有效率分别为 76 %、81% ,2药比较差异不显著。原发性中度高血压患者 2药有效率分别为 85 % ,70 % ,示非洛地平组高于硝苯地平缓释片组 ,2药比较有显著差异。 2药在治疗后心率均下降 ,与用药前比较有非常显著差异 ,但 2药间比较差异不显著。结论 :2药降压作用均显著 ,具有服药方便、副作用小等优点 ,适于单独应用治疗原发性轻、中度高血压。
Objective:To compair the efficacy of felodipine and nifedipine GITS in the treatment of essential hypertension.Methods:124 patients were randomly divided into felodipine treatment group (n=66) and nifedipine GITS reatment group (n=58).Felodipine treatmetn gruop was treated with felodipine (5mg,qd,po).Nifedipine GITS trearment group was treaded with nifedipine GITS (30mg,qd,po).The duration of treatmet was 8 weeks.Results:After the treatment by the two drugs,the clinical effective rate was 79%,80% respectively.No significant difference was found between these two groups.For mild hypertensive patients,the effective rate was 76%,81 respectively.No signficant difference was found between these two groups.Formoderate hypertensive patients,the effective rate was 85%,70% respectively .There was significant difference between these two groups.The heart rate decreased significantly after treatment in these two groups.But no significant difference was found between these two groups.Conclusion:Both of felodipine and nifedipine GITS are effective and safe hypertensive agent and suitable to patients with essential hypertension respectively and the incidence of adverse effect was rare in both groups.\;
出处
《河南职工医学院学报》
2001年第2期116-117,共2页
Journal of Henan Medical College For Staff and Workers