苦参碱注射液联合甘利欣治疗慢性乙肝疗效观察

Therapeutic effects of matrine and diammomium glycyrrhizinate injection on chronic hepatitis B

目的 寻找治疗慢性乙肝的有效方法。方法 慢性乙型肝炎患者随机分为治疗组 30例 ,对照组 40例 ,治疗组在对照组使用甘利欣基础上加苦参碱注射液 ,比较两组治疗前后TBil、ALT、AST以及HBsAg、HBeAg、HBeAb的变化。 结果 治疗组TBil、ALT、AST下降优于对照组 (P <0 0 5 ) ;HBeAg转阴率 ,HBeAb转阳率亦优于对照组 (P <0 0 5 ) ;HBsAg转阴率两组差异无显著性 (P >0 0 5 )。

AIM To seek the effective methods on treating chronic hepatitis B. METHODS We studied 70 patients who had been randomly divided into treatment group 30 and control group 34. Both groups were given diammonium glycyrrhi zinate injection. The treatment group was treated by matrine injection (150 mg, q d iv). We can compare liver function. (TBil, ALT and AST) and the changes of HBsAg, HBeAg and HBeAb before and after being examined. RESULTS In the treatment group the levels of TBil, ALT and AST were obviously reduced ( P< 0 05), HBeAg negative 40%(10/25), Anti HBe changed to be positive 33 3% (10/30). Both of changes were obviously superipr to the control group ( P< 0 05), HBsAg negative 3 3% (1/30) was not obviously different from ones ( P> 0 05). CONCLUSION Matrine and diammonium glycyrrhizinate injection may improve liver function and inhibit HBV.