可溶性P-选择素、血小板激活因子与急性心肌梗死的关系

The Soluble P-selectin and Plasma PAF in the Patient with AMI

目的:探讨P-选择素、血小板激活因子(PAF)水平变化在急性心肌梗死的意义。方法:用ELISA法测定30例急性心肌梗死(AMI)及对照组20例隐匿性冠心病(LCHD)患者的P-选择素、PAF水平,同时测定末梢血WBC计数、N%及心肌酶谱。结果:AMI患者的可溶性P-选择素、PAF明显增高。可溶性P-选择素,PAF与末梢血WBC计数,N%、心肌酶谱及AMI的面积呈正相关。结论:可溶性P-选择素,PAF在AMI患者明显增高,与炎性反应有关。

Purpose:To discuss the significance of plasma level changes of soluble P-selectin and PAF in patient with AMI.Methods:The plasma levels of P-selectin and PAF were measured among AMI (n = 30) and control group LCHD (n= 20 ) using ELISA method. Mean while WBC、N% and myocardial enzymes(CK-MB、 LDH1) were measured . Results:The plasma levels of P-selectin and PAF were much higher in AMI than control group( P <0.01). There were a correlation between plasma level of P-selectin or PAF and the change of my-ocardial enzymes, as well as the ischemic area of AMI. Conclusions:Plasma level of P-selectin or PAF were high-er in AMI,they were related with inflammatory reaction.