原发性肝癌患者手术前后细胞免疫指标的变化

The change of cellular factor in perioperative patients with hepatocellular carcinoma

目的:探讨原发性肝癌（HCC）患者手术前后若干细胞免疫指标的改变及其意义。方法:采用APAAP检测T细胞亚群（T-SL）,用双抗体夹心的ELISA法检测可溶性白细胞介素Ⅱ受体（sIL-2R）、白细胞介素-6（IL-6）、白细胞介素-8（IL-8）,免疫扩散法测定免疫抑制性酸性蛋白（IAP）了解29例HCC患者手术前后免疫功能。结果;HCC患者低于正常人（P<0.05）,术后7天变化不大,术后14天较手术前1天明显增高（P<0.05）,术后28天最明显（P<0.01）。结论:切除HCC病灶有助于HCC患者免疫功能的恢复。

Objectiver:To study the change of immunologic function in hepatocellular carcinoma(HCC) before and after operation . Methods: In 29 cases of HCC, T-SL was detected by APAAP, sIL-2R、IL-6、IL-8 were measured by ELISA, and through immunodif fusion, TAP was observed. Results: The immunologic f untion of the 29 cases of HCC was lower than normal control (P < 0.05). The cellular factors have no change on 7 day after operation. On 14 day after operation (P<0.05), the celluar factors were higher than those on 1 day before operation and changed significantly on 28 day after operation (P<0.01).Conclusions:The result suggested that it could improve the immunologic function of the patient after remove HCC.