进口左氧氟沙星在健康人体内的药代动力学

Pharmacokinetics of Imported Levofloxacin in Chinese Healthy Volunteers

目的：为探讨进口左氧氟沙星在国人体内的过程特点，对８名男性健康志愿者单剂口服左氧氟沙星片剂后的药代动力学进行了研究。方法：采用微生物法测定口服本品后不同时间血清中药物浓度，药一时数据用３Ｐ８７软件经微机处理。结果：口服本品后的体内过程符合一房室开放模型，主要药动学参数，如吸收半衰期、消除半衰期、峰时间、峰浓度、药一时曲线下面积、表现分布容积分别为（０．１５±０．０９）ｈ、（４．３４±０．４８）ｈ、（１．１０±０．３０）ｈ、（２．５７±０．６１）ｍｇ／Ｌ、（１３．１３±２．３９）ｍｇ·ｈ·Ｌ－１、（９９．２０±１１．２８）Ｌ。结论：国人左氧氟沙星药动学特点与国外报道相似。

To study the pharmacokinetics of levofloxacin after administration of a single oral dose of 200mg to each of 8 chinese healthy volunteers. Methods: The serum concentrations of levofloxacin at various time were determined by microbio- logic method. The data of serum level- time were processed with 3P87 software and microcomputer. Results: The data of imported tablet conformed to one-compartment open model. The main pharmacokinetic parameters, such as t1/2α,t1/2β,tmax, AUC and V/F,were (0. 15±0. 09)h, (4. 34 ± 0. 48)h, (1. 10 ± 0. 30)h, (2. 57 ±0. 61)mg/L, (13. 13 ± 2. 39)mg·h·L-1 and (99. 20 ± 11. 28)L. Conclusion: The pharmacokinetics of levofloxacin in Chinese healthy volunteers is similar to that reported abroad.