肝硬化患者血清一氧化氮的变化及意义

The Change and Significance of Serum Nitric Oxde in Patients with Hepatocirrhosis

目的：了解肝硬化患者血清一氧化氮的变化，并探讨其与肝硬化高动力循环及肝硬化腹水的关系。方法：采用Ｇｒｅｓｓ方法检测３５例肝硬化患者及２５例正常人血清一氧化氮水平。结果：肝硬化患者血清一氧化氮水平为（７０．２３±１８．６５）ｕｍｏｌ／Ｌ，正常组为（４６．７２±１０．６）ｕｍｏｌ／Ｌ，合并腹水者其一氧化氮含量为（８３．７６±２０．６）ｕｍｏｌ／Ｌ，高于肝硬化无腹水者（６０．３７±１７．５４）ｕｍｏｌ／Ｌ。肝硬化患者血清一氧化氮水平与肝硬化的病因无关。结论：肝硬化患者血中一氧化氮水平增高，有腹水者更高，提示一氧化氮可能与肝硬化高动力循环的形成有关，并在肝硬化腹水的发病机制中起一定作用。

Objective: To observe the change of serum nitric oxide (NO) in patients with with Hepatocirrhosis and disscuss the rela- tionship between NO and hyperdynamic circulation, and cirrhotic ascites. Methods: by using Griss methods, No levels of 35 cases and 25 cases Hepatocirrhosis were determinded and 25 normal cases. Results: In cirrhotic patients, the NO level was 70.23±18.65 umol/L; in normal group that was 46.72±10.6umol/L. Comparing with control, the NO level was increased in patients with cirrhosis, the NO level in cirrhosis with ascites (83.7±20.6umol/L) was higher than that of cirrhosis without ascites (60.37± 17.5umol/L). The NO level has no relation with the causes of cirrhosis. Conclusion: In patients with cirrhosis, the NO level was0 increased, especially in patients with ascites, which suggests that NO may relate to the formation of cirrhotic hyperdynamic circula- tion, and may play a role in the pathogenesis of cirrhotic ascites.