摘要
脑萎缩是一种常见的老年性疾病,严重影响老年人的生命健康。脑萎缩的病因和发病机理非常复杂,多种疾病和因素均可以引起脑萎缩。影像学以及病理检查可以早期发现并确诊脑萎缩的发生。到目前为止,尚无有效的治疗方法。本文着重综述了脑萎缩发病机理中遗传因素、脑缺血缺氧、免疫感染、神经毒素等因素的作用机制以及病理、影象学和治疗方面的进展。
出处
《国外医学(老年医学分册)》
2001年第6期252-257,共6页
Foreign Medical Sciences(Geriatrics)
参考文献39
-
1[1]Water HR,Hodes RJ,Pocinki K.What does cell death have to do with a ging.J Am Geriatr Soc,1997;45:267~279
-
2[2]Smith DE,Roberts J,Gage FH et al. Age-associated neuronal atrophy occur s in the primate brain and is reversible by growth factor gene therapy.Proc Natl Acad Sci USA,1999;96(19):10893~10898
-
3[3]Yasuda M,Mori E,Kitagaki H et al. Apolipoprotein E epsilon 4 allele and whole brain atrophy in late-onset Alzheimer`s disease.Am J Psychiatry,1998;155( 6):779~784
-
4[4]Halliday GM,McRitchie DA,Macdonald V et al. Regional specificity of bra in atrophy in Huntington`s disease.Exp Neurol,1998;154(2):663~672
-
5[5]Ni JW,Takahashi M,Yatsugi S et al. Effects of YM872 on atrophy of subst antia nigra reticulata after focal ischemia in rats.Neuroreport,1998;9(16):3719~3724
-
6[6]Smith DH,Chen XH,Pierce JE et al. Progressive atrophy and neuron death for one year following brain trauma in the rat.SO-J Neurotrauma,1997;14(10):715~727
-
7[7]Elovaara I,Sabri F,Gray F et al. Upregulated expression of Fas and Fas ligand in brain through the spectrum of HIV-1 infection.Acta Neuropathol (Berl), 1999;98(4):355~362
-
8[8]Zimmer J,Kistensen BW,Jakobsen B et al. Excitatory amino acid neurotoxi city and modulation of glutamate receptor expression in organotypic brain slice cultures.Amino Acids,2000;19(1):7~21
-
9[9]Brigitte P,Christopher E.Henderson H.Neuronal cell death.Neuron,1998;20. 633~664
-
10[10]Deckwerth T,Elliott L,Knudson JL et al. BAX is required for neur onal death after trophic factor deprivation and during development.Neuron,1997;1 7:401~411
同被引文献26
-
1郝宏毅,马泽红,王喜全,余跃忠.脑萎缩的分型与血压、血糖、血脂的等级相关分析[J].宁夏医学杂志,2004,26(10):610-612. 被引量:1
-
2蓝炼生.脑萎缩患者TCD探测脑血流量的改变[J].海南医学,2006,17(8):84-85. 被引量:3
-
3李冬梅,韩仲岩.缺血性脑血管病患者血清TNF-α和IL-10检测及意义[J].山东医药,2007,47(22):99-100. 被引量:2
-
4吴恩惠.头部CT诊断学[M].北京:人民卫生出版社,1984.105-106.
-
5Gotovac N, Isgum I, Viergever MA, et al. Calcium at the carotid siphon as an indicator of internal carotid artery stenosis[ J]. Europe- an Radiology, 2013, 23: 1467.
-
6Abdulrahman ALM, Ahmed S, Me|hem ER, et al. Carotid calcium scoring may correlate in males with the traditional Framingham cpi- demiologic risk variables for stroke[ J:. Surgical Neurology, 2009, 71 : 197.
-
7Agatston AS, Janowitz WR, Hildner FJ, et aL Quantification ofcor- onary artery calcium using ultrafast computed tomography [ J ]. Am Coil Cardiol, 1990, 15: 827.
-
8Vassilouthis J, Richardson AF. Ventricular dilation and communica- ting hydrocephalus following spontaneous subarachnoid hemorrhage [J]. J Neurosurg, 1979, 51: 341.
-
9Feldmann E, Daneault N, Kwan E, et al. Chinese-white differences in the distribution of occlusive cerebrovascular diseaseE J]. Neurolo- gy, 1990, 40: 1541.
-
10马敬民.??阿茨海默病的快速进展型脑中颞叶萎缩(J)国外医学(老年医学分册). 1995(04)
引证文献5
-
1毕莉莉,齐玲,李景辉,李净潜.老年脑萎缩患者血清中TNF-α表达[J].中国实验诊断学,2011,15(2):335-336. 被引量:2
-
2蔡志刚,李丽新.老年人脑萎缩与颈内动脉虹吸部钙化积分的相关性研究[J].临床神经病学杂志,2015,28(2):81-83. 被引量:3
-
3王露,楚兰,刘芳.大脑前部和后部皮质萎缩患者认知功能变化及神经心理学特点[J].中国老年学杂志,2018,38(11):2578-2580. 被引量:1
-
4高智玉.“缺血性脑白质病变”是慢性缺血造成的吗?[J].医学争鸣,2019,10(2):33-35.
-
5刘师兵,于洋,李松岩,王晓军.浅论人胎盘组织液对衰老大鼠小脑内浦肯野细胞形态的影响[J].当代医药论丛,2015,13(22):1-2. 被引量:1
二级引证文献7
-
1金宏,张宇,于洪泉,齐玲,严海,闫月馨,孟天娇.肿瘤坏死因子相关凋亡诱导配体联合化疗药物对胶质母细胞瘤细胞的杀伤作用[J].中风与神经疾病杂志,2011,28(7):639-640. 被引量:1
-
2严海,张宇,于洪泉,齐玲,金宏,姜亚磊,胡晓勇.肿瘤坏死因子相关凋亡诱导配体对胶质瘤细胞的诱导凋亡作用[J].中国实验诊断学,2011,15(8):1355-1356. 被引量:1
-
3姜于凤.脑萎缩老年患者合并脑出血实行综合护理干预措施的效果探析[J].中国继续医学教育,2016,8(11):254-254. 被引量:6
-
4张实秋.脓毒症患者认知功能障碍的危险因素调查[J].国际精神病学杂志,2022,49(4):713-716.
-
5孔祥飞.人胎盘组织液风池穴注射治疗痉挛性斜颈验案[J].中国民间疗法,2022,30(17):102-103. 被引量:1
-
6陈鹏(综述),李凯(审校).脑小血管病影像特征与颅内动脉钙化相关性的研究进展[J].实用放射学杂志,2024,40(7):1192-1194.
-
7陈恩海.老年脑萎缩伴精神障碍患者40例头颅CT检查的影像学表现[J].实用医技杂志,2019,26(3):294-296. 被引量:5
-
1鞠树红.阿尔茨海默病与功能磁共振检查[J].家庭用药,2008(8):64-64.
-
2卢山.创伤后应激障碍的研究现状[J].河北精神卫生,1997,10(4):260-262.
-
3范德义.腔隙性脑梗死115例临床分析[J].卒中与神经疾病,2003,10(6):372-372. 被引量:2
-
4赵春生,杨树源.脑脓肿影象学概况[J].国外医学(临床放射学分册),1991,14(6):334-336.
-
5杨军克.基底节区腔隙性脑梗塞82例CT扫描与分析[J].右江医学,1998,26(3):170-171.
-
6常莺莺,方国祥.偏头痛的病因和发病机理[J].贵医译丛,1989(1):17-20.
-
7李大年.偏头痛的病因和发病机理[J].山东医药,1992,32(9):34-34.
-
8李国辉,刘梅.针刺治疗紧张性头痛40例[J].中国民间疗法,2012,20(5):9-10. 被引量:9
-
9李玮.惊恐障碍的病因和发病机理研究[J].国外医学(精神病学分册),1990,17(4):201-204. 被引量:12
-
10梁东辉,黄国志.论老年痴呆症的本虚标实及中西医结合诊治[J].中华临床医学卫生杂志,2006,4(9):33-35. 被引量:1