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选择性雌激素受体调节剂—盐酸雷洛昔芬的研究进展 被引量:8

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摘要 本文对雷洛昔芬构效关系、组织选择效应、不良反应等临床资料进行综述。虽然雌激素仍是大多数绝经后妇女进行激素治疗的备选药物,但对于其中某些骨质疏松者,在权衡利弊后,雷洛昔芬可作为替代药物。
作者 张毅
出处 《国外医学(老年医学分册)》 2001年第6期275-278,共4页 Foreign Medical Sciences(Geriatrics)
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同被引文献45

  • 1马玉贞,张延岭,丁洁,张广洲.多司马酯的波谱特征与结构确证[J].分析化学,2005,33(2):225-228. 被引量:4
  • 2宋艳玲,赵燕芳,孟艳秋,宫平.盐酸雷洛昔芬的合成改进[J].中国新药杂志,2005,14(7):882-884. 被引量:3
  • 3Bryant HU.Mechanism of action and preclinical profile of raloxifene,a selective estrogen receptor modulation.Rev Endocr Metab Disord,2001,2(1):129-138.
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  • 5Johnston CC Jr,Bjarnason NH,Cohen FJ,et al.Long-term effects of raloxifene on bone mineral density,bone turnover,and serum lipid levels in early postmenopausal women:three-year data from 2 doubleblind,randomized,placebo-bontrolled.Intern Med,2000,160(22):3444-3450.
  • 6Ettinger B,Black DM,Mitlak BH,et al.Reduction ofvertebral fracture risk in postmenopausal women with osteoporosis treated with raloxifene.JAMA,1999,282(7):637-645.
  • 7Sambrook PN,Geusens P,Ribot C,et al.Alendronate produces greater effects than raloxifene on bone density and bone turnover in postmenopausal women with low bone density:results of EFFECT(Efficacy of FOSAMAX versus EVISTA Comparison Trial)International.J Intern Med,2004,255(4):503-511.
  • 8Barrett-Connor E,Mosca L,Collins P,et al.Effects of raloxifeme on cardiovascular events and breast cancer in postmenopausal women.N J Engl J Med,2006,355(2):125-137.
  • 9王埕 王玉.盐酸雷洛昔芬可用于治疗或预防骨质疏松症及降低乳腺癌的风险[J].药学进展,2008,32(2):93-93.
  • 10Gozansky WS,Van Pelt RE,Jankowski CM,et al.Protection of bone mass by estrogens and raloxifene during exercise-induced weight loss.J Clin Endocrinol Metab,2005,90(1):52-59.

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