中药NZ有效部位ZD的提取分离及抗炎免疫作用

The study of extract effective section (ZD) from Chinese traditional herbs (NZ) and its anti-inflammation and immune effects.

目的 :提取中药NZ的有效部位 (简称ZD) ,进行初步的结构鉴定实验 ;对ZD的抗炎及免疫实验进行初步实验研究。方法 :以小鼠耳肿胀模型 ,大鼠足跖肿胀模型和大鼠棉球肉芽肿模型评价ZD的抗炎作用 ;利用小鼠植物血凝素 (PHA)刺激淋巴细胞转化实验评价ZD的免疫作用。结果 :ZD对小鼠二甲苯性耳肿胀、角叉菜胶所致大鼠足跖肿胀和大鼠棉球肉芽肿模型均有显著抑制作用 ;同时在小鼠PHA刺激淋巴细胞转化实验中显示具有免疫增强作用。结论

Objective:Extract effective section(ZD) from NZ and identify the structure;study its anti-inflammation and immune effects.Methods:Use dimethybenzene-induced mouse ear edema,carrageenan-induced rat paw edema and cotton-peller-induced rat granuloma models to evaluate the anti-inflammation effect; phytohemagglutinin(PHA)-induced lympocyte transform model is also used to evaluate the immune effect of ZD.Results:ZD has obvious effect to inhibit the edema and granuloma in animal models and enhance the immune ability of mouse.Conclusions:ZD has good effect to inhibit the inflammation and enhance the immune ability.