2型糖尿病血管病变与血脂代谢紊乱关系的研究

Study on relationship of vascular disease and dyslipidemia in patients with type 2 diabetes mellitus

目的 :为观察 2型糖尿病血管病变与血脂代谢紊乱的关系。方法 :分析 5 5例糖尿病患者和 30例正常人的血糖和血脂。结果 :(1)糖尿病患者组与正常对照组比较提示 ,其血糖及血脂的各项指标 :总胆固醇 (TC) ,甘油三酯 (TG) ,高密度脂蛋白 (HDLC) ,低密度脂蛋白 (LDLC) ,载脂蛋白A1(ApoA1) ,载脂蛋白B(ApoB) ,以及α -脂蛋白 [LP(a) ]有非常显著的差异 (P <0 0 1或P <0 0 5 )。TG ,TC ,LDLC ,ApoB均升高 ,HDLC ,ApoA1下降。 (2 )糖尿病无血管病变组的血脂与对照组比较仅有TG、ApoA1,ApoB浓度改变有显著差异 (P <0 0 5 ) ,其他无显著差异。然而有血管病变组较对照组血脂浓度改变均有极显著意义(P <0 0 1) ,以及病程延长 (P <0 0 1)。 (3) 2型糖尿病组中 ,有血管病变组LDLC ,ApoB ,LP(a)水平较无血管病变组升高 ,而ApoA1,A1/B下降 ,在统计学上有显著性差异 (P <0 0 5或P <0 0 1)。结论 :提示 2型糖尿病患者血清血脂中TG、TC、LDLC、ApoB、LP(a)水平升高是患血管并发症的危险因素 ,而HDLC ,ApoA1作为抗动脉粥样硬化的良好指标则明显下降。

Objective:To observe the relations between vascular disease and dyslipidemia in patients with type 2 diabetes mellitus (DM).Methods:The blood glucose and lipid of 55 DM cases and 30 cases normal persons (control group) were compared Results:(1)Compared with the control group,the blood glucose and blood lipid meters of DM group varied significantly (P<0 01 or P<0 05) The level of Triglyceride(TG), cholesterol(TC),Lowdensity lipoprotein(LDLC),ApoproteinB(ApoB) were higher but the Highdensity lipoprotein (HDLC),ApoproteinA 1(ApoA 1)were lower (2)When the blood lipid of the diabetes group without vascular disease compared with the control group,only the change of the TG,ApoA 1,ApoB density had significance (P<0 05),others without significance But the blood lipid density of vascular disease group was higher than that of the control group(P<0 01),and the course of disease was longer (P<0 01) (3)In DM group,the patients with vascular disease had higher LDLC,ApoB,α-Lipoprotein ,but lower ApoA 1 and rate of A 1/B than those of the without vascular disease group,there was statistical significance (P<0 05 or P<0 01) Conclusion:The results indicate that the raise of the TG,TC,LDLC,ApoB,LP(a) in the diabetes are the risk factors of the vessel complications of DM As the good meters for anti-sclerose,the HDLC,ApoA 1 are lower obviously \;