糖皮质激素对肾病患儿血清中细胞因子的影响

Effect of Glucocorticoid on Serum Cytokines in Children with the Nephrotic Syndrome

目的 探讨糖皮质激素对肾病综合征 (NS)患儿血清中白细胞介素 1(IL 1) ,白细胞介素 6 (IL 6 ) ,白细胞介素 8(IL 8)和肿瘤坏死因子α(TNFα)的影响。方法 将 2 4例NS患儿分为激素治疗前和治疗后两组 ,应用间接酶联免疫吸附试验 (ELISA)检测血清中IL 1,IL 6 ,IL 8和TNFα的水平。结果 NS患儿激素治疗前后血清中IL 1[(195± 2 5 )ng/Lvs (12 0± 2 5 )ng/L],IL 6 [(35 5± 6 2 )ng/Lvs (2 0 0± 2 3)ng/L],IL 8[(2 86± 5 5 )ng/Lvs (178± 32 )ng/L]和TNFα[(2 6 5± 36 )ng/Lvs (110± 40 )ng/L]水平差异有显著性意义 (P <0 .0 1)。

Objective To explore the effect of glucocorticoid on serum IL 1, IL 6, IL 8 and TNFα in children with the nephrotic syndrome (NS). Methods IL 1, IL 6, IL 8 and TNFα in serum were detected using ELISA in 24 children with NS before and after the treatment with glucocorticoids. Results Significant differences of IL 1 [(195±25) ng/L vs (120±25) ng/L], IL 6 [(355±62) ng/L vs (200±23) ng/L], IL 8 [(286±55) ng/L vs (178±32) ng/L] and TNFα [(265±36) ng/L vs (110±40) ng/L] were found between the two groups before and after the treatment (P< 0.01 ). Conclusions It is suggested that glucocorticoids might inhibit serum IL 1, IL 6, IL 8 and TNFα in children with NS.