长期吸入糖皮质激素对哮喘患者某些骨代谢指标的影响

Effects of long term inhaled steroid therapy for asthma on bone density and calcium metabolism

目的 了解南京地区哮喘患者长期吸入类固醇糖皮质激素 (GCS)是否有引起骨质丢失的可能。方法 采用双能X线骨密度仪 (DEXA)和放免法等分别测定 2 0例每日坚持吸入GCS大于等于五个月的哮喘患者的骨密度 (BMD)、血骨钙素 (BGP)等指标 ,并同期配对 2 0例未使用GCS的哮喘患者进行对比分析。结果 显示两组病人BMD和BGP等各指标之间比较差异无显著性 ,P >0 0 5。结论 提示在一定限度内长期吸入GCS控制哮喘 。

Objective To investigate whether prolonged treatment with inhaled steroids has a detrimental effect on bone mass and metabolism. Methods\ We measured bone density and osteocalcin in 20 asthmatic subjects after treatment with an inhaled steroid for more than 5 months,and compared them with a control group of 20 asthmatic subjects using no steroids. Results\ There are no significant differences between the two groups in bone density and other markers of bone metabolism( P >0 05). Conclusion\ Long term inhaled steroids,in the range of doses used,has no adverse effects on bone density and other makers of bone metabolism in asthmatic patients.