摘要
探讨了宫内低水平铅暴露对新生儿神经行为发育的影响。 1 38例维汉母子 (维 5 9例 ,汉79例 )血铅测定由上海儿童铅中毒防治中心采用石墨炉原子吸收光谱法。用NBNA方法做新生儿2 0项神经行为测定。结果表明 ,( 1 ) 1 38例产妇血铅 ( 1 2～ 2 67) μg/L ,新生儿脐血铅 ( 1 0～ 2 5 2 )μg/L ,维、汉母子血铅均呈高度正相关 (r =0 80 4 7,0 7898,P <0 0 1 )。其中维吾尔族孕妇及新生儿脐血铅均高于汉族 (P <0 0 1 ,P <0 0 5 )。血铅≥ 1 0 0 μg/L的孕妇 5 3例 ( 38 4 1 % ) ,新生儿 4 8例 ( 34 78% )。 ( 2 )新生儿脐血铅水平和新生儿神经行为 (NBNA)总评分及行为能力评分呈负相关 (P <0 0 1 ) ,主要影响新生儿非生物性听定向反应及生物性视和听定向反应 (P <0 0 5 ,P <0 0 1 )。提示本组维汉孕妇及新生儿脐血铅水平可以影响新生儿神经行为功能 ,且新生儿铅中毒在本地区有一定比率 。
To study the effect of intrauterine low level lead expossure on neonatal neurobehavioral development,maternal and umbilical blood lead levels were determined in 138 cases of neonates(79 cases of Han and 59 cases of Uygur)with graphite oven atomic absorption spectrometry,and indicatiors for neurobehavioral development were examined using NBNA.The results showed that among the 138 cases,maternal blood lead levels were(12～267)μg/L,umbilical blood lead levels were(10～252)μg/L.There were significant statistic correlation between blood lead levels of mothers and their babies' umbilical cords( r =0 8047,0 7898, P <0 01).Maternal and umbilical blood lead levels were higher in Uygur than that of Han( P <0 01, P <0 05).The blood lead level was ≥100 μg/L in 53 cases of pregnant women and 49 cases of neonates.(2)The umbilical blood lead levels had negative relationship with neonatal neurobehavioral ability score( P <0 01),especially with nonbiologically auditory and biological visual and auditory orientaion reaction( P <0 05, P <0 01).The umbilical blood lead level could cause adverse effects on neonatal neurobehavioral development,and neonatal lead poisoning in Uygur was relevant highter comparing with other areas.Enough attention should be paid to the situation.
出处
《广东微量元素科学》
CAS
2001年第10期25-29,共5页
Trace Elements Science
