摘要
提出核酸序列的矩阵表示形式,按位点定义了有生物学意义的信息参数M1(l)、M2(l)和M3(l)。着重研究了不同表达水平的大肠杆菌(Escherichiacoli,E.coli)的SD序列(Shine -Dalgarnoregion,SD)以及大肠杆菌(E.coli)和酵母菌(Yeast)基因起始、终止密码子邻近区域核酸序列的碱基关联性与保守性。并求出相应矩阵的本征值 ,给出了信息参量与基因表达水平的关系。发现信息参量体现了原核生物和真核生物翻译起始区域的显著差异 。
The matrix representation of nucleic acid sequences and the definition by M1(l)、M2(l) and M3(l)) are presented. The definition is biological of significance. The E.coli in different expression level were investigated for SD region. The conservative and correlative properties of the bases of the specific sequences between E.coli and Yeast genes were studied comparatively, and the eigenvalues of the corresponding matrix were calculated. The relation between informational parameters and gene expression level was given. The results show that the informational parameters indicate remarkable difference in the translated starting regions, and the conservativity of a single base and the correlation between base pair in the starting regions of eukaryote are stronger than those of prokaryote.
出处
《生物物理学报》
CAS
CSCD
北大核心
2001年第4期676-684,共9页
Acta Biophysica Sinica
基金
国家自然科学基金资助项目 (39660023)
