肾缺血预处理对心脏缺血/再灌注损伤的保护作用

THE EFFECT OF RENAL ISCHEMIC PRECONDITIONING ON THE MYOCARDIAL ISCHEMIC/REPERFUSION INJURY IN RABBITS

目的 :探讨肾缺血预处理对家兔心脏缺血 /再灌注 (I/R)损伤的影响及意义。方法 :32只大耳白家兔随机分为假手术(SO)、心脏 1/R、经典缺血预处理 (CIPC)及肾缺血预处理 (RIPC) 4组。观察各组心肌梗塞面积、左室舒缩功能、心脏超微结构及心律失常发生率的变化。结果 :CIPC、RIPC组 ,心肌梗塞面积、再灌性心律失常发生率较I/R组明显降低 ,左室舒缩功能明显恢复 (P <0 .0 1) ,心脏超微结构损伤明显减轻。结论

Aim: To investigate whether renal ischemic preconditioning could protect myocardium from ischemic reperfusion injury. Methods: Thirtytwo adult white rabbits were randomly divided into four groups: group sham operation (SO), myocardial ischemic reperfusion (I/R), classical ischemic preconditioning (CIPC ) and renal ischemic preconditioning (RIPC). Changes of left ventricular functions, myocardial infarct size, myocardial ultrastructure and cardiac arrhythmia were observed. Results: RIPC and CIPC could reduce the myocardial infarct size and the attack rate of arrhythmia(P<0.01 vs I/R);improve the left ventricular functions ( P < 0.01 vs I/R) and minized the ultrastructure injury of I/R myocardium. Conclusion: The RIPC might elicit a myocardial protection against ischemic reperfusion injury, which is similar to the effect of CIPC.