摘要
Mx蛋白是干扰素诱导表达的蛋白家族中的成员 ,当机体和细胞受病毒感染或诱生剂处理时产生。Mx蛋白和其它干扰素诱导蛋白一起构成宿主细胞的抗病毒状态 ,以达到抗病毒的目的。研究表明 ,Mx蛋白具有抗病毒活性 ,还可能与其它基本生命活动如发育或分化 ,蛋白质分送和生长有关。在鱼类也发现多种Mx蛋白 ,具有Mx蛋白家族的共有特征 :在肽链末端有一个三联ATP/GTP结合区和发动蛋白家族的结构特征序列 ;在蛋白C端存在使Mx蛋白形成三聚体的Leu拉链结构以及定位信号。但是迄今没有发现鱼类Mx蛋白的抗病毒活性。
Mx proteins are members of a family of interferon inducible genes expressed in organisms or cells which are treated with all sorts of inducers or virus infection.These proteins together with other interferon inducible proteins form the antiviral state in host cells and the first line of the body's defense against virus infection.Apart from the inhibtion of a specific virus,Mx proteins may be related with other basic cellular functions such as development/differentiation,protein sorting and growth.Mx proteins in several fishes are found and a comparsion of their sequences with that of avian and mammalian species reveals striking conservation of domains.They all maintain a tripartite ATP/GTP binding motif and a signature of the dynamin family in the amino terminal of the protein.In addition,the C terminal region of the Mx proteins contains the localization signals and the leucine zipper motif which account for the trimerization of Mx in the cell.So far,the antiviral function of the fish Mx proteins has not been satisfactorily established.In the end,this paper presents recent developments in prevention and treatment to fish viral diseases and some problems in fish antiviral brceding by using some antiviral genes.
出处
《中国病毒学》
CSCD
2001年第4期291-298,共8页
Virologica Sinica
基金
国家自然科学基金资助 (3 9870 60 2 )
