摘要
目的 :探讨肾衰康延缓慢性肾衰竭 (CRF)进展的疗效及机理。方法 :采用 5 / 6肾切除大鼠CRF模型 ,随机分为模型组、洛汀新组及肾衰康组治疗 ,观察各组Scr、BUN及尿中细胞外基质成分 (ECM )排泄量。结果 :洛汀新组及肾衰康组Scr及BUN均显著低于模型组 (P <0 0 1及P <0 0 5 ) ,而肾衰康组Scr又低于洛汀新组 (P <0 0 5 ) ,肾衰康组尿中Ⅳ型胶原 (Col-Ⅳ )、纤维连接蛋白 (FN)及层粘连蛋白 (LN)含量均明显比模型组高 (P <0 0 1)。结论 :肾衰康有延缓CRF进展的作用 ,其机理可能与促进ECM成分从尿中排泄 ,从而减轻肾小球内ECM的聚集有关。但肾衰康对ECM是抑制合成还是促进降解尚需进一步探讨。
Objective: To study the renoprotective effect and mechanism of Shenshuaikang in chronic renal failure. Methods: 5/6 nephretomized CRF rats were divided into 3 groups: model group, Lotensin group and shenshuaikang group. Scr, BUN and urinary secretion of ECM were measured in each group. Results: Scr was lower in Lotensin and Shenshuaikang group than that in the model group (P<0.01 and P<0.05,respectively). Scr was lower in shenshuaikang group than that in Lotensin group(P<0.05). The concentration of collagen IV, fibronectin and laminin in urine were significantly higher in Shenshuaikang group than that in model group(P<0.01). Conclusion: Shenshuaikang can protect from CRF though increasing secretion of ECM in urine and decreasing accumulation of ECM in glomeruli
出处
《中国中西医结合肾病杂志》
2001年第9期508-510,共3页
Chinese Journal of Integrated Traditional and Western Nephrology
基金
镇江市社会发展科技资助项目 (No .9932 0 30 )
关键词
慢性肾衰竭
肾衰康
细胞外基质
Chronic renal failure Shenshuaikang Extracellular Matrix
