摘要
目的 研究国产新药加巴喷丁 (GBP)的主要药效学。方法 抗惊厥试验采用最大电休克发作法 (MES)、士的宁惊厥法及戊四唑最小发作法 (MET)。结果 GBP片剂 (30～ 96 0mg·kg-1,ig)呈剂量依赖性对抗小鼠的MES及MET ;GBP片剂 (6 0～ 480mg·kg-1,ig)也能对抗士的宁引起的小鼠惊厥。结论 GBP片剂有明显的抗惊厥作用。
AIM To study the main pharmacodynamics of Gabapentin(GBP) tablet. METHODS The maximal electrshock seizure(MES) , strychnine-induced convulsion and minial threshold seizure(MET) were adopted in anticonvulsant test. RESULTS GBP tablet (30?60?120?240?480?960 mg·kg -1 ) had significantly anticonvulsant action in MES and MET with dose-dependent manner in mice; GBP tablet(60?120?240?480 mg·kg -1 ) had also significantly anticonvulsant action in mice induced by strychnine. CONCLUSION GBP table had anticonvulsant action with significance.
出处
《安徽医药》
CAS
2001年第2期91-93,共3页
Anhui Medical and Pharmaceutical Journal
关键词
加巴喷丁
药理学
癫痫
药物疗法
惊厥
Gabapentin/pharmacology
epilepsy/drug therapy
convulsion/drug therapy
