原发性肝癌综合序贯介入治疗与肝动脉栓塞化疗的对比研究

A Study of the Therapeutic Effect of Combination and Sequential Interventional Treatment on Primary Liver Cancer Against that of Hepatic Arteria Chemo Embolization

目的 探讨原发性肝癌的综合序贯介入治疗的临床应用价值。方法 对 82例肝癌随机分为综合治疗组 38例和肝动脉栓塞化疗 ( TAE)组 44例。综合治疗组采取序贯进行 TAE、B超引导下门静脉栓塞化疗、肝癌无水酒精注射治疗及 B超引导下门静脉癌栓无水酒精注射治疗。结果 综合治疗组和 TAE组存活 0 .5a以上分别为 36例 ( 94.7% )和 32例 ( 72 .7% ) ;1 a以上分别为 2 6例 ( 6 8.4% )和 1 8例 ( 4 0 .9% ) ;2 a以上为 1 2例 ( 31 .5% )和 4例 ( 9.1 % ) ;综合治疗组存活 3a以上 3例 ( 7.9% ) ,最长生存 42个月 (存活 ) ,TAE组最长生存 30个月 (死亡 )。两组相比 ,差异有显著性 ( P<0 .0 5)。结论 综合序贯介入治疗的 0 .5a、1 a、2 a及 3a生存率均较单纯 TAE组显著延长。

Objectives To study the clinical value of combination and sequential interventional treatment on primary live cancer.Method 82 cases of liver cancer were divided into two groups in random,among which there were 38 case in combination treatment group and 44 in TAE treatment group.In the combination treatment group, the cases were given treatment in sequence as below: TAE, percutaneous transhepatic portal chemoembolization under B type ultrasonic induction, ethanol injection treatment for the liver cancer and ethanol injection for protal venous thrombus under B type ultrasonic induction.Result In combination treatment group and in TAE treatment group, the cases who's survival period longer than half of a year were 36 cases(94.7%) and 32 cases(72.7%) respectively,the survival period longer than 1 year were 26 cases (68.4%) and 18 cases(40.69%)respectively ,and the survival period longer than 2 years were 12 cases(31.5%) and 4 cases (9.1%) respectively.There were 3 cases who survived more than 3 years in the combination treatment group, and the longest survival period was 42 months in the combination treatment group as the patients is still alive. On contrary, the longest survival period was 30 months in TAE group while the patient died in the end. The difference between the two groups was significant(P<0.05).Conclusion The 0.5 year, 1 year,2 year and 3 year's survival rate in the combination and sequential interventional treatment group are significantly higher than that of the TAE group.