原发性肾病综合征并发感染的危险因素

Risk factors for infection in primary nephrotic syndrome

目的 :探讨原发性肾病综合征并发感染的危险因素。方法 :利用回归分析方法评价原发性肾病综合征的临床特征和生化指标与感染的关系。结果 :在 12 2例原发性肾病综合征中 ,感染发生率为 2 2 .1% ;血清IgG水平低于 5 .0g/L者与高于 5 .0g/L者比较 ,发生感染的相对危险性为 3.14(P <0 .0 1) ;血清肌酐高于 177μmol/L者与低于177μmol/L者比较 ,发生感染的相对危险性为 4.77(P <0 .0 1)。结论

Objective:To investigate the risk factors for infection in primary nephrotic syndrome.Methods:Correlation between clinical or biochemical characteristics and infection in primary nephrotic syndrome was evaluated by regression analysis.Results:The incidence of infection was 22.1% in 122 consecutive patients with primary nephrotic syndrome.The relative risk for infection was 3.14 among patients with serum IgG level below 5.0 g/L compared with patients over 5.0 g/L(P<0.01).The RR was 4.77 among patients with serum creatinine level over 177 μmol/L compared with patients below 177 μmol/L(P<0.01).Conclusion:hyppogammaglobulinemia and renal insufficiency are independent risk factors for infection in patients with primary nephrotic syndrome.