血小板膜GpⅣ、GpⅤ在慢性ITP发病中的意义

The Pathogenetic Signifiance of Platelet Glycoprotein Ⅳ and Glycoprotein Ⅴ in Chronic Idiopathic Thrombocytopenic Purpura

目的:了解血小板GpⅣ、GpⅤ在慢性ITP发病中的意义。方法:采用改良的单克隆抗体免疫固定特异血小板抗原(MAIPA)的方法检测38例慢性ITP患者血浆抗GpⅣ、GPⅤ抗体水平,评估GpⅣ、GpⅤ在慢性ITP中的意义。结果:在38例患者中,1例抗GpⅤ抗体阳性,阳性率为2.6％;2例抗GpⅣ抗体阳性,阳性率为5.3％,并且在这2例患者中,1例同时存在血浆抗GpⅡb/Ⅲa抗体。结论:(1)GpⅣ是慢性ITP自身抗体的一个靶抗原,并且在某些患者体内可同时存在抗GHⅡb/Ⅲa自身抗体。(2)在慢性ITP,GpⅤ分子上亦含有自身抗体的靶抗原。

Objective: To clarify the pathgcnctic importance of platelet GpⅣ and GpⅤ in chronic idio-pathic thrombocytopenic purpura( ITP). Methods: The plasma autoantibodies against GpⅣ or GpⅤ in patients with chronic TTP(n=38) were measured by using a modified monoclonal antibody specific immobilization of platelet antigens(MAIPA) assay. The pathogenetic importance of GpⅣ and GpⅤ in chronic ITP was valuated. Results: In 38 patients with chronic ITP, specific antibodies against GpⅣ were found in two patients, and was coexist with antoantibodies against Gp Ⅱb/Ⅲa in one patient; GpⅤ-specific antibodies were found in one patients. The positive rate were 5.3% and 2. 6% respectively. Conclusion: (1)GpⅣ was a target antigen of plasma antuantibodies in chronic ITP, and was coexist with Gp Ⅱ b/Ⅲa antoantigen in some patients. (2)GpⅤ was an important scarce target antigen in chronic ITP.