摘要
目的 探讨肿瘤坏死因子-α（TNF-α）、可溶性肿瘤坏死因子受体（sTNFR）及血浆一氧化氮（NO）在充血性心力衰竭（CHF）发生和发展中的作用与相互关系。方法 用断面调查的方法,采用双抗体夹心法测定了68例CHF患者血浆中TNF-α和sTNFR水平,用高效液相法测定了血浆NO的变化,并与30例正常人进行对照。结果 检测结果表明,不同程度的 CHF患者血清中上述指标均发生明显的改变,与对照组比较存在显著差异（P<0.01）,TNF-α,sTNFR和NO三者之间存在明显正相关,并随心力衰竭程度的加重而增加。结论TNF-α及NO水平的变化是影响CHF发生和发展的重要因素。
Objective To explore the effects of tumor necrosis factor-alpha, soluble tumor necrosis factor receptor and nitric oxide on the pathogenesis of congestive heart failure and the relationship among them. Methods A cross-sectional study design was employed. The serum levels of tumor necrosis factor-alpha, soluble tumor necrosis factor receptor were determined with double-biotin-system ELISA in 68 hospitalized patients with congestive heart faolure and 30 normal controls. And the concentration of nitric oxide in plasma was detected with high-performance liquid chromatography (HPLC). Results There were significant differences in all the three parameters between patients and controls (P <0. 01) . Each of the parameters was positively correlated with the rest of others. Conclusions It was suggested that changes in levels of tumor necrosis factor-alpha and nitric oxide might play an important role in the development of congestive heart failure.
