抗心磷脂抗体与脑卒中关系的探讨

Study of the Relationship between Aticardiolipin Antibody and Cerebral stroke

目的：检测血清抗心磷脂抗体 (ACA)并探讨其与脑卒中的关系。方法：使用酶联免疫吸附试验 (ELISA)，检测 76例脑梗死患者， 42例脑出血患者以及 50名正常人的血清 ACA。结果：脑梗死组 ACA阳性率为 39. 47％，与脑出血组 (19. 05％ )和正常对照组 (8. 00％ )比较差别具有显著性 (P0. 05)。进一步分析，复发性脑梗死患者和首发性脑梗死患者 ACA阳性率分别为 61. 90％和 30. 91％，两者比较差异有显著性 (P69％ )。结论： ACA与缺血性脑卒中的发病有一定关系，尤其与复发性脑梗死关系更为密切， ACA检测对缺血性脑卒中的预防、治疗和病情预后评估有价值。

Objective: To dertermine the serum Anticardiolipin Antibody (ACA)and reseach the relationship between ACA and cerebral stroke.Methods:The serum ACA were tested by enzyme linked immunosorbent assay (ELISA) in 76 patients with cerebral infarction,42 patients with cerebral hemorrhage and 50 healthy controls.Results: The positive rate of ACA was 39.47％ in cerebral infarction group,19.05％ in cerebral hemorrhage group(P0.05). There was significant difference(P69％ ).Conclusion: ACA has relation with the occurrence of ischemic cerebral stroke,especially in recurrent cerebral infarction. Detection of ACA is valuable in prevention, treatment and clinical activity evaluation of ischemic cerebral stroke.