不同剂量辛伐他汀调脂作用的比较

Comparision of the Lipid-regulating effect with Carious dose of simvastatin

目的：比较不同剂量辛伐他汀对高脂血症患者的调脂作用。方法： 43例高脂血症患者随机分为两组，分别接受 10mg/d(A组 )和 20mg/d(B超 )辛伐他汀治疗，服药前及服药后 8w测定血脂。结果： (1)用药 8w后两组中总胆固醇 (TC)及低密度脂蛋白胆固醇 (LDL-C)水平较治疗前均有明显降低。 (2)B组中甘油三酯 (TG)水平明显降低 (P<0. 05)，高密度脂蛋白胆固醇 (HDL-C)明显升高 (P<0. 01)，而在 A组 TG及 HDL水平则无明显变化。 (3)两组治疗 8w后脂蛋白 (a)[LP(a)]水平与治疗前比较均明显降低 (P<0. 05)。 (4)两组降低血脂的有效率分别为 68. 75％和 90. 32％，两者比较有明显差异 (P<0. 01)。结论：辛伐他汀每天 20mg才能达到满意的调脂效果。

Objective: To compare the lipid-regulating effects of simvastatin with various dose in patients with hyperlipidemia.Methods: 43 patients with lipidemia were randomly divided into group A and group B, all were received 10mg/d and 20mg/d simvastatin resp-ectively.Serum lipid profile was determined before and 8 weeks after the treatment.Results: (1)After 8 weeks of treatment,serum total cholesterol (TC) and low density lipoprotein cholesterol(LDL-C) levels were decreased in two groups. (2)Serum triglyceride (TG) level was decreased and high density lipoprotein cholesterlo (HDL-C) level was increased in group B, both TG and HDL-C didn't change in group A(P>0.05). (3) The lipoprotein (a)level decreased in both groups after 8 weeks of treatment. (4)In two groups,serum lipid profile were lowered in effective rate of 68.75％ and 90.32％ .Conclusion: 20mg/d simvastatin was more effective.