白细胞介素-1β对缺氧培养神经元的损伤作用

Effect of IL -1βon hypoxia neurons survive

目的探讨白细胞介素－１β（ＩＬ －１β）对缺氧培养神经元的作用。方法应用四唑盐比色法（ＭＴＴ）染色检测ＩＬ －１β对缺氧培养神经元存活的影响。结果ＩＬ －１β对正常培养的神经元活性无明显影响，但可显著降低缺氧培养神经元的活性。结论ＩＬ －１β可能与其他损伤因子共同作用，参与了缺氧后的病理损伤。

Objective Interleukin -1β(IL -1β)plays a key role in the pathogenesis o f cerebral ischemia.In this study we will observe the effect of IL -1βon hypoxia neurons survive.Method MTT staining was used to detected the survial neurons.Result IL -1βhad no effect on normal cultured neur ons,but it could decrease the number of hypoxia cultured neurons.Conclusion IL -1βhad the deteriorative function on hypox ia cultured neurons.