Mechanism exploration on effects of cardiac sympathetic anesthesia on cardiac performance of dilated cardiomyopathy

Objective To explore the mechanism of effects o f cardiac sympathetic anesthesia on left ventricular ejection fraction(LVEF)and left cardiac cavity size of patie nts with dilated cardiomyopathy.Method121consecutive patients with dilat ed cardiomyopathy were divided into cardiac sympathetic nerve blockade group(TEAgroup)and control group(c group).In TEAgroup,5%lidocaine was injected into thoracic epidural cavity for about 4to 8weeks in addition with routine therapy.In c group,only routine therapy was use d.We observe the changes of LVEF and left cardiac cavity size before a nd after treatment in both groups.Result I n TEAgroup,after anesthesia,LVEF w as increased from(31.3±12.8)to(47.3±21.3),P <0.001;left ventricular end -dia stolic diameter was reduced from(69.1±7.1)to(65.1±8.0),P <0.001;left atrial diameter was decreased from(44.0±6.2)to(39.4±7.2),P <0.001.Conclusion Cardiac sympathetic anesthesia can effectively improve the ejectio n performance of dilated cardiomyopathy and make the dilated cardiac cavity turn to normal level.