卡维地洛固体分散体的研制及其体外溶出实验

Preperation of Carvedilol Soliod Dispersion and Dissolution Experiment in Vitro

目的:制备卡维地洛固体分散体,增加其溶解度和溶出速度。方法:以聚乙烯吡咯烷酮(PVP)、聚乙二醇-6000(PEG-6000)为载体,溶剂法和溶剂熔融法制备固体分散体,并进行体外溶出度研究。结果:载体比例越大,药物溶出愈快;且载体比例愈小,差异愈显著。载体为PVP所制固体分散体的体外溶出行为总体优于载体为PEG-6000的固体分散体。结论:本试验所制卡维地洛固体分散体能加速体外溶出,为难溶于水药物提高生物利用度开辟一条途径。

Objectives: To improve the dissolution of carvedilol. Method: carvedilol solid dispersions were prepared by solvent-melting and coevaporation methods with PEG-6000 and PVP as carriers, the study on the dissolution was conducted in vitro. Result: The results showed that the higher the ratio of carrieer: carvedilol the faster the drug dissolution would be; The smaller the ratio was , the bigger the difference would be. The dissolution of solid dispersions could dispersions with PEG-6000 at the carrier in vitro. Conclusion: Accelerate the rate of release in vitro and improve bioavailability.