肝脏调节急性出血坏死性胰腺炎患者血清IL-6水平的作用

The Serum IL-6 Level is Mediated by the Liver in the Rats with Acute Necrotizing Pancreatitis

目的 探讨肝脏在急性出血坏死性胰腺炎中所起的作用。方法 将Wistar大鼠分为对照组、门腔静脉分流组、急性出血坏死性胰腺炎组、门腔静脉分流后急性出血坏死性胰腺炎组 ,观察各组生存时间。同样再分 4组 ,3h后 ,测定每组动物血清和 (或 )腹水中IL - 6水平。结果 门腔静脉分流后急性出血坏死性胰腺炎组存活时间明显减少 ,与其他各组比较 ,差异有显著意义 (P <0 .0 1) ,其血清IL - 6水平明显高于其他各组 ,差异有显著意义(P <0 .0 5 )。急性出血坏死性胰腺炎组腹水中IL - 6水平明显高于血清IL - 6水平 (P <0 .0 1) ,且高于门腔静脉分流后急性出血坏死性胰腺炎组腹水中IL - 6水平 (P <0 .0 5 )。结论 肝脏在急性出血坏死性胰腺炎的早期起保护作用 。

Objective To evaluate whether liver plays a protecting role in rats with acute necrotizing pancreatitis(AP),and the role of the liver in mediating serum IL-6 level.Methods The Wistar rats were divided into four groups randomly:control group,potocaval shunting group(PC),AP group,potocaval shunting performed immediately before taurocholate infusion into the pancreatic duct group(PC+AP),the survival time was recorded.The same four groups were distributed as in the previous series.In this case,3 hours after the surgical procedure,serum and/or ascites IL-6 levels were measured.Result PC+AP group survival times were shorter than the other groups( P< 0.01),but its serum IL-6 level was higher than the other groups( P< 0.05).IL-6 level of ascites in AP group was much higher than serum IL-6 level in every group( P< 0.01),and even higher than IL-6 level of ascites in PC+AP group.Conclusion Liver plays a protecting role in rats with acute necrotizing pancreatitis,which may be as a barrier preventing toxins from portal vein into systemic circulation in early stage.