摘要
目的 :调查异氟烷改善缺血后心肌功能的作用是否与腺苷A1受体有关。方法 :5组 (n =8)离体大鼠心脏Langendorff法灌注。全心缺血 2 0min ,再灌注 12 0min。记录分析应用异氟烷和 (或 )腺苷A1受体拮抗剂(DPCPX)后再灌注期舒张末期压 (EDP)、左室发展压 (DP)、室内压最大上升速率 (LV +dp/dtmax)和室内压最大下降速率 (LV dp/dtmin)的变化。结果 :异氟烷明显降低再灌注期EDP ;增强DP、LV +dp/dtmax和LV dp/dtmin的恢复(P <0 0 5 )。缺血前或缺血后给予DPCPX不能减弱异氟烷的保护作用 (P >0 0 5 )。结论 :异氟烷增强离体大鼠心脏缺血后的功能恢复 。
Objective:To determine whether isoflurane induced myocardial protection is mediated by adenosine receptor subtype A 1 Methods: Five groups ( n =8) of isolated rat hearts were studied in the Langendorff apparatus The hearts were subjected to 30min global ischemia and 120min reperfusion DP, EDP, LV+dp/dt max and LV dp/dt min were recorded and analyzed after administrating isoflurane and (or) adenosine receptor antagonist (DPCPX) Results: Isoflurane significantly decreased EDP and improved the recoveries of DP, LV+dp/dt max and LV dp/dt min during reperfusion compared with control groups( P <0 05) DPCPX administrated before or after the global ischemia couldn′t attenuate the protection of isoflurane ( P >0 05) Conclusion: Isoflurane enhances the post ischemic functional recovery of isolated rat heart and A 1 receptors are not involved in isoflurane induced myocardial protection
出处
《军医进修学院学报》
CAS
2001年第4期291-293,共3页
Academic Journal of Pla Postgraduate Medical School
