爆炸冲击波对肺微血管通透性影响的研究

Study of the effect of explosive blast on the pulmonary microvascular permeability

目的 探讨爆炸性冲击波对肺微血管通透性损伤的量效关系。方法 采用雷管对兔的爆炸性冲击损伤模型 ,以及12 5I-白蛋白标记的方法 ,观察爆炸性冲击波对兔肺微血管通透性的影响。结果 距爆源 2 0cm处的爆炸冲击波作为爆炸冲击波对肺微血管通透性影响的临界点 ,该处压力平均峰值为 174 4kPa ,红细胞压积的增加为 14 9% ,血浆丢失为对照组的 5 12倍 ,白蛋白漏出率为伤前的 1 3倍 ,左肺组织中残留放射性较对照组增加约 18%。结论 10 0kPa以上的爆炸冲击波能引起红细胞压积明显增加 ,血浆丢失 。

Objective The dose-effect relationship between the explosive blast and pulmonary microvascular permeability changes has been explored.Method The model of explosive blast wounded on rabbits and the method of 125 I-aibumin dilution have been used.Results The site of 20 cm far from explosive center is a critical site which will induce the pulmonary microvascular permeability changes.On this site,average peak pressure is 174.4 kPa,hematocrit increased 14.9%,the loss of plasma is 5.12 fold compared with control group,the rate of 125 I-albumin escaped is 1.3 fold compared with control group,the remained in left lung tissue increased approximately 18%.Conclusion The explosive blast of over 100 kPa can cause hematocrit increase,plasma loss,albumin escaped from circulation increase,and the remained radiation in lung tissue increase.