CT定向组织间插植高剂量率近距离放射治疗术后胶质瘤疗效分析

Postoperative radiotherapy of glioma by CT guided interstitial irradiation brachytherapy of high dose rate

目的 评价比较ＣＴ定向组织间插植高剂量率近距离后装内放疗胶质瘤术后残瘤的疗效。方法 对１３例胶质瘤术后残瘤患者进行脑内插置后装内放疗，内放疗组在术后 １～２周内进行，剂量分割为 ２０Ｇｙ／３ｆ／２周；对照组外放疗剂量分割为 ６０ Ｇｙ／３０ｆ／２周。结果 随访１～４年，与对照组比较，接受后装治疗的患者肿瘤局部控制而并发症少。结论ＣＴ定向组织间插植高剂量率近距离后装内放疗术是治疗术后胶质残瘤又一可行方法，它能够减少并发症，控制肿瘤生长，改善残瘤局部控制。

Objective To evaluate the effect of postoperative radiotherapy of glioma by CT guided interstitial irradiation brachytherapy of high dose rate. Methods 13 patients with residual glioma after surgical removal were randomizd into brain brachytherapy group and control group. In brachytherapy group, patients received internal radiation for 20 Gy/3f/2w 1 - 2 weeks after operation. In control group, patients received external radiation with the total dose of 60 Gy/30f/2w. Results All patients were followed up for more than 1 - 4 years. Patients received brachytherapy had better local tumor control and less complications than those in control group. Conclusion CT guided interstitial irradiation brachytherapy of high dose rate is a better method in treating residual glioma after surgical removal. It reduces complications and has better control of residual glioma.