摘要
目的研究硫苷脂对烧伤延迟复苏大鼠远隔脏器损伤的保护作用。方法SD大鼠给予30 %Ⅲ度烧伤延迟复苏 ,伤后随机分为对照组和硫苷脂治疗组。在烧伤后9h,测定两组动物肺、心、肝、肾的血管通透性、含水量、髓过氧化物酶 (MPO)活性。结果硫苷脂治疗组在伤后9h ,肺、心、肝、肾的血管通透性明显降低 ,MPO活性明显减少。结论硫苷脂对烧伤延迟复苏大鼠远隔脏器血管通透性的增高有保护作用。硫苷脂对中性粒细胞聚集的抑制是其重要机理之一。
Objective To study the effects of sulfatide on the enhancement of vascular permeability in severe burned rats after delayed fluid resuscitation.Methods SD rats received 30% TBSA, full_thickness burn injury and received delayed resuscitation. Burned rats were divided into control group and sulfatide treated group. The tissues of lung, heart, liver and kidney from rats were obtained 9h postburned to measure the vascular permeability, water content and myeloperoxidase(MPO).Results Vascular permeability, water content and MPO significantly attenuated in sulfatide treated group compared with the delayed resuscitation group.Conclusions Our results indicate that sulfatide inhibits the enhancement of vascular permeability in severe burned rats with delayed resuscitation, via reduced PMN accumulation.
出处
《中国微循环》
2001年第4期267-267,270,共2页
Journal of Chinese Microcirculation
基金
上海市医学领先专业基金资助(作者说明 :此基金无资助编号)
关键词
烧伤
血管通透性
硫苷脂
延迟复苏
Burns
Vascular permeability
Sulfatide
Delayed fluid resuscitation
