白细胞介素6与慢性乙型肝炎患者肝细胞损伤和纤维化的关系

The Relationship of IL 6 to Hepatic Cell Damage and Fibrosis of Chronic Hepatitis B Patients

目的 :探讨血清白细胞介素 6 (IL - 6 )与慢性肝病的关系。方法 :采用 EL ISA法和放免法对 76例慢性乙型肝炎 (CHB)、肝炎肝硬化 (L C)、慢性重型肝炎 (CSH)患者血清 IL- 6和 型前胶原蛋白 (PC )及 型胶原蛋白 ( C)测定 ,肝活检 42例进行肝组织病理学分析。结果 :1CHB轻、中、重度、L C、CSH患者血清 IL- 6水平分别为 (2 9.93±8.0 8) pg/ m l、(5 0 .36± 4.5 1) pg/ ml、(78.33± 9.11) pg/ ml、(71.5 9± 8.2 3) pg/ ml、(96 .13± 5 .47) pg/ ml,依次升高 (P<0 .0 1或 P<0 .0 5 ) ;明显高于对照组 (7.10± 1.80 ) pg/ ml。 2血清 IL- 6水平与 PC 及 C呈正相关 (P<0 .0 1) ,与肝组织炎症损伤及纤维化程度亦呈正相关。结论 :IL-

Objective: To study the relationship between serum IL 6 level and chronic hepatopathy. Methods: Serum IL 6 level、procollagenⅢ(PCⅢ) and collagenⅣ(ⅣC) of 76 patients suffering chronic hepatitis B(CHB) or cirrhosis of the lives (LC) or chronic hepatitis gravis (CSH) were assayed by ELISA and RIA. Liver histopathological analyses of 42 patients were performed by liver bropsy. Results: (1) Serum IL 6 levels of mild, Moderate or serious CHB patients and LC or CSH patients were (29 93±8 08)pg/ml、(50 36± 4 51) pg/ml 、(78 33±9 11) pg/ml、(71.59±8.2) pg/ml and (96 13±5 47) pg/ml. They were all much higher than (7 10±1 80) pg/ml of control (P<0 01 or P<0 05). (2) Serum IL 6 levels showed positive corrective with PCⅢ and ⅣC(P<0.01). Conclusion: IL 6 level had a mutual relation with degree of chronic hepatopathy.