血吸虫病人血清体外诱导杀童虫作用的观察

IN VITRO KILLING SCHISTOSOMULA EFFECTS INDUCED BY SERA FROM SCHISTOSOMA JAPONICUM-INFECTED PERSONS

通过比较日本血吸虫感染病人与正常人血清体外诱导小鼠白细胞杀童虫的作用 ,了解抗体依赖的细胞介导的细胞毒作用 (ADCC)在血吸虫感染宿主的获得性免疫中的作用。体外诱导小鼠白细胞杀童虫作用 ,日本血吸虫感染病人血清 ,无论是成人组还是儿童组 ,初次感染组还是重复感染组 ,均明显地强于正常人血清 ,表明抗血吸虫特异性抗体可以诱导细胞介导的细胞毒作用。证明日本血吸虫感染宿主体内存在着 ADCC机制 ,该机制对于抵抗再次感染具有一定的作用 。

The study is trying to understand the role of antibody dependent cell mediated cytotoxicity (ADCC) in the acquired immunity of Schistosoma japonicum infected host by comparing killing schistosomula effects of mice macrophage, eosinophil and other cells induced by human sera from infected persons or normal individuals. The results showed that the sera from infected persons could induce much stronger killing effects than that of the sera from normal individuals. It has been suggested by the authors that the antibody specific for S.japonicum could induce cell mediated cytotoxicity, and that ADCC exists in infected host and plays a role in resistance of reinfection.