摘要
哺乳动物胎肺的发育可以分 5个时期 :胚胎期、假腺期、小管期、囊状期和肺泡期。人、绵羊和山羊胎儿至出生时肺的发育已基本完善 ,处于肺泡期 ;而兔、大鼠和小鼠的胎儿至出生时肺的发育尚处于囊状期。肺泡表面上皮细胞的分化和气血屏障的形成是肺发育的形态学标志。呼吸功能的建立 ,与 II型上皮细胞的分化密切相关。II型细胞的分化标志有以下几点 :1糖原的变化 ;2粗面内质网池扩张 ,并出现絮状物质 ;3多泡体出现及高尔基小泡增多 ;4胞质内微管出现 ;5腔面生成微绒毛 ;
Pre and postnatal lung development in mammals is divided into five Periods:embryologic, pseudoglandular,canalicular,saccular and alveolar period.The fetal sheep lung at term is far more advanced in terms of alveolar formation than the human fetal lung. These two species are further advanced than either the rabbit, rat, or mouse, each of which shows large saccular structures in the lung but no detectable alveoli at birth. Differentiation of alveolar surface epithelial cells and formation of blood-air barrier are the morphological markers of lung development. The differentiation markers of type II cells are as follow:①change of glycogen;②rough endoplasmic reticulum pools expand and floccular materials appear;③multivesicular bodies are observed and Golgi vesicles increased;④vasculation in cell plasmogen;⑤microvilli of the epithelial cells appear on the luminal surface;⑥the lamellar bodies are observed in dense bodies.
出处
《动物医学进展》
CSCD
2001年第4期29-31,共3页
Progress In Veterinary Medicine
关键词
形态
发育
胎肺
哺乳动物
morphology
development
prenatallung
mammal
